Medical Research Awards for 2011
Dr Felix Randow - MRC Laboratory of Molecular Biology
How do cells defend their cytosol against invading bacteria and could failure cause inflammatory bowel disease
£73,110 (2 years)
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Dr. David Wilson - University of Edinburgh
Establishment of UK & Irish IBD Genetics Group
£50,000 (1 year)
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Dr Miles Parkes - Addenbrookes Hospital
UK IBD Genetics Consortium study of anti-TNF pharmacogenomics and IBD genetics in the UK South Asian population
£30,000 (2 years)
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Dr Stuart Taylor - University College Hospital
Magnetic Resonance Imaging derived mural perfusion dynamics in Crohn’s Disease: Pathophysiology and prediction of disease relapse
£28,999 (2 years)
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Dr Andrew Stagg - Barts and The London School of Medicine and Dentistry
PhosphoFlow analysis of gut-homing blood cells in Crohn’s Disease activity
£5,840 (1 year)
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Medical Research Awards for 2011
totalled: £187,949
Medical Research Awards for 2010
Dr Timothy Card - Division of Epidemiology and Public Health, Nottingham City Hospital
An examination of aspects of the occurrence natural history and consequences of inflammatory bowel diseases utilising available electronic records.
£98,939 (2 years)
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Professor Christopher Mathew - Department of Medical and Molecular Genetics, Kings College, London School of Medicine
Whole Gene Sequencing in Familial Crohn’s Disease
£77,749 (1 year)
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Professor Andrew Silver and Dr James Lindsay - Centre for Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry
Tissue and serum miRNA expression profiles in stricturing Crohn’s Disease: evaluating their potential in disease assessment and treatment
£69,298 (1 year)
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Medical Research Awards for 2010
totalled: £245,986
Medical Research Awards for 2009
Prof. Munir Pirmohamed - Department of Pharmacology
The University of Liverpool
Sherrington Building
Ashton Street
Liverpool, L69 3GE
Investigation of the role of ABCB5 in corticosteroid transport and response in IBD
£119,942 (2 years)
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Prof. Mohammad Ilyas - School of Molecular Medical Sciences
Divisin of Pathology
Queens Medical Centre
Nottingham, NG7 2UH
The Role of the stem cell marker CD24 during the healing phase of inflammatory bowel disease
£118,571 (2 years)
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Dr James Lee - Cambridge Institute for Medical Research
BOX139 Wellcome Trust/MRC Building
Addenbrookes hospital
Hills Road
Cambridge, CB2 2XY
The application of gene expression profiling in inflammatory bowel disease to predict disease behavior
£81,981 (2 years)
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Medical Research Awards for 2009
totalled: £320,494
Medical Research Awards for 2008
Professor Christopher Probert - Clinical Science South Bristol, Bristol Royal Infirmary
Steroid Resistant Lymphocyte Populations in Ulcerative Colitis
£100,000 (2 years)
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Dr Barry Campbell - University of Liverpool, Division of Gastroenterology
Identifying the molecular mechanisms of interaction between colonic Crohn's disease mucosa-associated Escherichia coli and the intestinal epithelium
£89,341 (2 years)
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Professor George MacFarlane - Gut Group, Division of Pathology and Neuroscience
Synbiotic treatment of ulcerative colitis patients
£86,950 (2 years)
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Dr David Qualtrough - Department of Cellular & Molecular Medicine, University of Bristol
The role of Notch signalling in restitution, regeneration and remission in inflammatory bowel disease
£7,791 (1 year)
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Medical Research Awards for 2008
totalled: £284,082
Medical Research Awards for 2007
Professor David Rampton - Endoscopy Unit, Royal London Hospital
How does Psychological Stress Exacerbate Ulcerative Colitis? Roles of mucosa-associated bacteria, mast cells and catecholamines
£85,000 (2 years)
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Dr Christine Whiting - School of Clinical Veterinary Science, University of Bristol
IL-13 promotes inflammation-induced gut fibrosis via a TNF-?-dependent mechanism
£67,106 (1 year)
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Dr Jeremy Sanderson - School of Biomedical and Health Sciences, Kings College London
The difficult problem of oral Crohn’s disease: a unique pathological entity in IBD?
£51,975 (1 year)
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Dr Louise Langmead - Department of Gastroenterology UCLH
Clinical trial to evaluate aloe vera gel enemas in mild to moderately active distal ulcerative colitis (UC)
£30,127 (1 year)
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Dr Jeremy Sanderson - School of Biomedical and Health Sciences, Kings College London
Optimising thiopurine metabolite monitoring to allow personalised thiopurine treatment
£9,300 (1 year)
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Medical Research Awards for 2007
totalled: £243,508
Medical Research Awards for 2006
Prof Subrata Ghosh - Imperial College London
Control of adaptive immune responses via Crohn’s disease-associated NOD2 signalling and bacterial sensing in human dentritic cells
£95,242 (2 years)
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Dr Amanda Williams - University of Bristol
Is selection pressure responsible for chronic refractory IBD? – Does initial steroid therapy ultimately lead to treatment failure by preferential selection of disease-propagating T cells?
£89,987 (2 years)
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Dr Andrew Smith - University College London
Macrophages from Crohn’s disease patients have an impaired response to inflammatory stimuli
£20,000 (1 year)
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Dr Gordon Dent - Keele University
Eosinophil/epithelium interactions in inflammatory bowel disease: a pilot study
£3,000 (1 year)
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Medical Research Awards for 2006
totalled: £208,229
Medical Research Awards for 2005
Professor Christopher Mathew - Guys, King’s & St Thomas’ School of Medicine
Genetic investigation of the role of the NF-kB pathway in susceptibility to inflammatory bowel disease
£89,946 (2 years)
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Professor John Hermon-Taylor - St George’s Hospital Medical School, London
Progress in the development of a prime/boost MVA/Ad5 vectored vaccine against Mycobacterium avium subspecies paratuberculosis (MAP) to treat MAP-infected Crohn's disease sufferers
£89,242 (2 years)
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Dr Geoffrey Warhurst - University of Manchester
A novel role for P-glycoprotein in regulating the interaction between the colonic epithelium and commensal gut bacteria: implications for the pathogenesis of inflammatory bowel disease
£67,339 (2 years)
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Dr Miles Parkes - Addenbrooke’s Hospital
Cambridge and Eastern IBD genetics: expanding the large-scale region-wide IBD DNA panel; Genome Partitioning to map the IBD2 locus; and analysis of Crohn's disease data from Sanger Institute case/control study
£25,501 (18 months)
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Dr David Qualtrough - University of Bristol, School of Medical Sciences
The Role of Fascin in IBD related cancer risk
£5,756 (1 year)
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Medical Research Awards for 2005
totalled: £277,784
Medical Research Awards for 2004
Dr Satish Keshav - Department of Medicine, Royal Free & University College Medical School, London
Tissue-specific and circulating effectors in Crohn’s disease.
£85,000 (2 years)
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Professor Gordon Dougan - Centre for Molecular Microbiology and Infection, Dept.of Biological Sciences, Imperial College London, London
Isolation and characterisation of E.coli in inflammatory bowel disease.
£77,741 (2 years)
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Professor Derek Jewell - Gastroenterology Unit University of Oxford, Nuffield Dept. of Medicine, Radcliffe Infirmary, Oxford
Identification of a susceptibility gene on chromosome 3 for Crohn’s disease.
£75,000 (2 years)
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Professor Subrata Ghosh - Gastroenterology Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London
A prospective study of the intestinal expression of vanilloid receptor 1 in symptomatic Crohn’s disease patients and its relationship to inflammation and Crohn’s Disease Activity Index score.
£42,500 (2 years)
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Dr Miles Parkes - Addenbrookes NHS Trust, Cambridge
Cambridge and Eastern region IBD genetics.
£41,455 (1 year)
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Dr John Mansfield - Royal Victoria Infirmary, Newcastle-upon-Tyne
Histological Correlation with Genetic Variation in Crohn’s Disease
£38,000 (1 year - Funded by the Margaret Sim Legacy)
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Medical Research Awards for 2004
totalled: £359,696
Medical Research Awards for 2003
Dr Barry Campbell - Gastroenterology Research Group, University Clinical Department of Medicine, Liverpool
Investigation of IL-8 release by mucosally-adherent E.coli and Bacteroides species relevant to pathogenesis of inflammatory bowel disease.
£76,790 (2 years)
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Dr Satish Keshav - Dept of Medicine, Royal Free and University College, London NW3 2PF
New targets in IBD: Crohn’s Disease, the NOD2 gene and Paneth cells.
£74,723 (2 years)
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Dr Jeremy Sanderson - Gastroenterology Department, St Thomas’s Hospital, London
Predictive Pharmacogenomics of Thiopurine Bowel Disease.
£36,812 (1 year)
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Dr Mark Pritchard - Department of Medicine, Liverpool University, Liverpool
Investigation of the importance of the gastrin family of peptides and gastrin/CCKB receptor in inflammatory bowel disease.
£29,887 (1 year)
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Dr Jeff Behrens - Lecturer, University of East Anglia, Norwich
Can Wireless Capsule Endoscopy be of use in assessing small bowel Crohn’s Disease ? – A pilot study assessing the possible role of colour as well as traditional computer vision methods to pathogenesis of Inflammatory Bowel Disease?
£5,995 (1 year)
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Dr Geoffrey Warhurst - Gut Barrier Group, Clinical Sciences Building, University of Manchester, Manchester
Colonic gene expression in a novel model of colitis: preliminary evaluation of the molecular mechanisms by which a primary defect is the mucosal barrier leads to IBD.
£5,920 (1 year)
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Medical Research Awards for 2003
totalled: £230,127
Medical Research Awards for 2002
Dr Peter Irving - Barts and The London School of Medicine and Dentistry
Platelet-Leucocyte Aggregation in Inflammatory Bowel Disease.
£79,809 (2 years)
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Professor Jack Satsangi - Gastrointestinal Laboratory, University of Edinburgh Dept. of Medical Sciences
Gene-environmental interactions in Inflammatory Bowel Disease: the effects of NOD-2 mutations and nicotine on NF-kB activation.
£76,775 (2 years)
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Professor Derek Jewell - Department of Gastroenterology, Oxford
Identification of the HLA susceptibility gene for colonic Crohn’s disease by targeted positional cloning and microarray expression studies.
£44,838 (1 year)
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Dr Timothy Card - School of Community Health Sciences, University Hospital, Nottingham
A very large population based study of the morbidity and mortality related to Inflammatory Bowel Diseases.
£28,542 (1 year)
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Miss Miranda Lomer - Gastrointestinal Research Laboratory, The Rayne Institute, St Thomas’ Hospital, London
Assessment of large pore (particulate) permeability: A pilot study.
£5,992 (2 months)
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Dr Satish Keshav - Dept of Medicine, Royal Free & University College Medical School, London
Chimeraplast-mediated gene therapy for Crohn’s Disease.
£5,800 (9 months)
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Medical Research Awards for 2002
totalled: £241,756
Medical Research Awards for 2001
Dr S Pender - Southampton General Hospital
Functional polymorphism in the regulatory region of matrix metalloproteinase genes in Inflammatory Bowel Diseases.
£74,202 (2 years)
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Dr J Cummings - University of Dundee
The toxicity of reduced sulphur compounds in the human large intestine: A novel approach to management of Ulcerative Colitis by dietary intervention.
£69,971 (conditional after 1 year)
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Dr H Burnett - Hope Hospital, Manchester
Magnetic Resonance Imaging of the terminal ileum using the TrueFISP sequence (True Fast Imaging with Steady Precession-2 weighted gradient echo), findings compared to small bowel enema (SBE).
£10,800 (9 months)
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Dr N Cook - Central Science Laboratory, York
Development of a NASBA-based method for detection of viable Mycobacterium paratuberculosis.
£6,000 (1 year)
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Dr S Keshav - Royal Free Hospital
Phosphoinositide-3-kinase ¡ expression in colorectal carcinoma associated with Inflammatory Bowel Disease.
£5,947 (1 year)
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Dr T Trebble - Southampton General Hospital
n-3 PUFA supplementation in paediatric Crohn’s Disease: effects on disease activity and growth.
£5,521 (6 months)
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Medical Research Awards for 2001
totalled: £172,441
Medical Research Awards for 2000
Dr D Rampton - Royal London Hospital
Adverse effects of oral iron therapy in IBD prevalence, mechanism and avoidance.
£74,655 (2 years)
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Dr S Bloom - Middlesex Hospital, London
Molecular analysis of colonic mucosal microflora associated with inflammatory bowel disease.
£35,527 (1 year)
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Dr S Middleton - Addenbrooke’s Hospital, Cambridge
Detection of mini chromosome maintenance proteins in stool samples and rectal lavage specimens. An alternative to surveillance colonoscopy in ulcerative colitis?
£35,500 (1 year)
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Dr D Robertson - Royal United Hospital, Bath
Investigating the contribution and possible interaction between NF-kB and P1-3 Kinase in the TNF- a induced signalling cascades in intestinal epithelial cells.
£6,000 (1 year)
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Mr O Ogunbiyi - Royal Free Hospital, London
Investigation of the relationship between inflammatory bowel disease and familial colorectal cancer.
£5,680 (2 years)
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Dr A Hart - West Norwich Hospital
The role of diet in the aetiology of Crohn’s disease and Ulcerative colitis - a pilot study in a European prospective cohort study.
£5,451 (1 year)
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Dr M Carter - Royal Hallamshire Hospital, Sheffield
Investigation of hyperhomocysteinemia as a cause of the increased risk of thrombosis in inflammatory bowel disease.
£4,000 (1 year)
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Medical Research Awards for 2000
totalled: £166,813
